ETS transcription factor GABP alpha essential for early embryogenesis.

2004 SEP 2 - (NewsRx.com & NewsRx.net) -- The ETS transcription factor GABP alpha is essential for early embryogenesis.

"The ETS transcription factor complex GABP consists of the GABPalpha protein containing an ETS DNA binding domain, and an unrelated GABPbeta protein containing a transactivation domain and nuclear localization signal.

"GABP has been shown in vitro to regulate the expression of nuclear genes involved in mitochondrial respiration and neuromuscular signaling. We investigated the in vivo function of GABP by generating a null mutation in the murine Gabp-alpha gene," investigators in Australia report.

"Embryos homozygous for the null …